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This video tutorial reviews EC coupling in Heart muscle cells:
0:00. Introduction
0:55. The anatomy of EC coupling
3:44. 1. AP propagates along membrane, down T-Tubule and activates L-type Calcium channel
4:02. 2. Ca flows into cell and binds to and activates the RyR receptor
4:20. 3. Enables SR to release Ca into the cytoplasm (Ca transient)
4:49. Guinea pig heart muscle cell contraction with Ca dye
5:40. 4. Rise in cytoplasmic Ca activates the myosin and actin to contract
6:02. Cytoplasmic Ca must decline for cell to relax (SERCA, NaCaX, Ca pump)
6:57. EPI and CCB influence on L-type Ca channels
7:40. In-A-Nutshell
8:21. Acknowledgements
The Noted Anatomist